Biphasic Effects of THC on Anxiety
THC's dose-dependent flip from calming to anxiogenic, supported by controlled human evidence but with highly i...
CBD and Addiction Research
A critical review of what science shows—and doesn't—about CBD in addiction treatment.
CBD and Antipsychotic Effects
Small clinical trials suggest CBD may reduce psychotic symptoms; larger studies are needed.
CBD and Anxiety
Strong evidence for one-time high-dose CBD before acute stressors; weak evidence for daily use.
CBD and Cyclosporine: Interaction Risks
Cannabidiol can raise cyclosporine blood levels through shared liver enzymes, creating a real but understudied...
CBD and Dravet Syndrome
FDA-approved pharmaceutical CBD cuts convulsive seizure frequency by roughly half in Dravet syndrome.
CBD and Lennox-Gastaut Syndrome
FDA-approved CBD reduces drop seizures in severe childhood epilepsy when added to existing treatment.
CBD and Methotrexate
A real interaction exists, but human evidence for benefit is absent.
CBD and Metoprolol: Drug Interaction Overview
What's actually known about combining cannabidiol with the beta-blocker metoprolol, and where the evidence get...
CBD and Sleep
CBD may help anxiety-driven sleep loss, but the science for general insomnia is weak.
CBD and Trazodone
What we know about combining cannabidiol with the sleep and antidepressant drug trazodone — mostly theoretical...
CBN and Sleep
One weak human trial; marketing vastly overstates the evidence base.
Cannabinoids and Apoptosis Research
Laboratory evidence for cannabinoid-induced cell death in cancer is consistent; human clinical data are sparse...
Cannabis Hyperemesis Syndrome (CHS)
Severe cyclic vomiting triggered by chronic heavy cannabis use; resolves on cessation.
Cannabis Pharmacokinetics: How Cannabinoids Move Through the Body
What happens to THC and CBD once they enter your body, route by route.
Cannabis Smoke vs Tobacco Smoke
Both produce harmful combustion byproducts, but evidence on long-term outcomes differs sharply.
Cannabis Tolerance and Sleep Effects
Short-term sedation, tolerance, rebound insomnia, and why long-term use often backfires.
Cannabis Use Disorder
A clinical diagnosis defined by impaired control, withdrawal, and harm—treatable with behavioral therapy and e...
Cannabis Use With Autoimmune Therapy
Cannabis may help manage some autoimmune symptoms but does not modify disease; interactions with immunosuppres...
Cannabis Use in Adolescence and Psychosis
High-potency cannabis in adolescence correlates with increased psychosis risk; causality is debated but popula...
Cannabis Use in Older Adults
What the evidence shows about cannabis benefits and risks for people over 65.
Cannabis Use in Pediatric Autism Research
Evidence review of cannabinoid use in autistic children, from seizure control to behavioral effects.
Cannabis Vaporization and Respiratory Effects
What vaporization does and doesn't do for respiratory health, backed by evidence.
Cannabis Withdrawal Syndrome
Real but not life-threatening withdrawal after heavy regular cannabis use.